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The Fermion Sign Problem (FSP) poses a significant challenge in computational quantum many-body physics, hindering the application of Quantum Monte Carlo (QMC) methods to Fermionic systems. This issue is due to the antisymmetric nature of Fermionic wavefunctions, which results in an exponential decay of the signal-to-noise ratio as system size and inverse temperature increase, leading to numerical instabilities in large-scale simulations. Despite extensive research over the years, a universal solution to this problem remains elusive, positioning it as a critical barrier for achieving accurate first-principles simulations in Fermi liquids, quantum chemistry, nuclear matter and lattice QCD. However, recent innovative strategies have shown promise in reducing the impact of the FSP within QMC simulations, as evidenced by comparisons with benchmark calculations for liquid 3He and warm dense matter simulations relevant to modeling novel inertial fusion technologies. This workshop aims to address these advancements and will focus on discussing recent breakthroughs in QMC methodologies, theoretical treatments of the sign problem, and effective mitigation strategies. Key topics will also encompass algorithmic innovations, mathematical frameworks, and practical applications in fields such as nuclear physics, condensed matter physics, quantum chemistry and warm dense matter, promoting collaboration and knowledge sharing among participants.