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The study of the QCD phase diagram in the high-muB region is a key avenue toward understanding strongly interacting matter under extreme conditions. First accurate data in the collision energy region around 10 GeV, corresponding to baryo-chemical potentials of several hundred MeV, became available recently, with the completion of the Beam Energy Scan at RHIC. Hadronic and electromagnetic observables were the main addressed topics. The next breakthrough is expected with the CBM/HADES experiments at FAIR/GSI and the proposed NA60+ experiment at SPS/CERN that will take data at interaction rates larger by at least two orders of magnitude, allowing a much more accurate study of electromagnetic probes and first results on heavy-quark production. Following an exploratory workshop held at ECT* in 2021, we now aim at substantial progress in reviewing currently available results, analyzing the physics potential of the forthcoming experiments, and discussing first actual predictions for the future measurements. We will also review the progress on new detectors for high-luminosity experiments, identifying possible developments and synergies between the various projects.