Conveners
Nanoscale radiation damage to DNA: experimental and modelling perspectives
- Gustavo Garcia Gómez-Tejedor (CSIC, Madrid, Spain)
In this talk, I will give an overview of the applications of nanodosimetry in particle therapy treatment planning [1]. My talk will summarize the underlying concepts of nanodosimetry and describe the development and current status of nanodosimetric detector technology. I will also give an overview of Monte Carlo track structure simulations that provide nanodosimetric parameters for proton and...
About 80% of the energy absorbed in cells exposed to high-energy ionizing radiation (IR), produces firstly ions and secondary electrons. These latter posse the largest portion of the deposited energy (E), with an initial energy distribution lying essentially below 30 eV and peaking around 9-10 eV. Although some low-energy (E<20 eV) electrons (LEEs) can further ionize biological tissues, they...
The interaction of low-energy electrons (LEEs) with DNA plays a significant role in the mechanisms leading to biological damage induced by ionizing radiation, particularly in radiotherapy, and its sensitization by chemotherapeutic drugs and nanoparticles [1]. Plasmids constitute the form of DNA found in mitochondria and appear as a suitable model of genomic DNA [2]. In a search for the best...