Conveners
Research on targeted radionuclide therapy and associated technologies
- Valeria Conte (Laboratori Nazionali di Legnaro LNL, Istituto Nazionale di Fisica Nucleare INFN, Legnaro, Italy)
Boron Neutron Capture Therapy (BNCT) is a radiotherapy that consists in patient irradiation with low energy neutrons after the administration of a tumour-targeting borated drug [1]. The thermal neutron capture in 10B generates two high-LET, short-range charged particles that cause non-reparable damages to the cell where the reaction takes place. Provided a suitable tumour-to-normal tissue...
Alpha emitters hold great promise to improve ligandtherapy or Targeted Alpha Therapy (TAT), where an alpha emitter is attached to a biological tracer. The tracer is injected into the blood stream of a cancer patient and accumulates over time in the cells with the targeted expression, e.g.cancer cells. As alpha particles have a relative high Linear Energy Transfer (LET), it typically causes...